Cyspera®
Intensive pigment Correction System
Cyspera®
Cyspera Intensive SystemTM is clinically proven to be fast and effective against hyperpigmentation without the concerns of corticosteroids, retinoic-acid and hydroquinone.
Hope for your Skin
Pigmentary disorders can be psychologically devastating
Your first line topical treatment, Hydroquinone free
Hydroquinone has been used for decades as the gold standard for stubborn discolouration concerns. Although still controversial, hydroquinone has a reputation as a mutagenic and carcinogenic compound. It is a melano-cytotoxic agent that is known to induce ochronosis. Non-hydroquinone compounds such as kojic acid, arbutin, azelaic acid, retinoids and hydroxy acids show lower efficacy.
Significant efficacy on melasma
2015, first double-blind, randomised clinical study on 50 epidermal melasma patients.2 Other clinical studies have confirmed results.3 – British Journal of Dermatology
Significant response of Kligman’s-resistant patients
Melasma lesions almost disappearing and signs of skin atrophy reversing after treatment with topical cysteamine.4
– Journal of Cosmetic Dermatology
Greater depigmenting effects than HQ4%
Comparison of Cyspera vs. HQ4% in a randomised controlled trial. Investigator concludes Cyspera as an alternative to avoid or rotate off HQ4%.5
– Australian Journal of Dermatology
Better efficacy & tolerability than Kligman
Formula Comparison of Cyspera vs. modified Kligman Formula in a randomised clinical study of 50 melasma patients.6
– Skin Research Technology
As effective with less complication than TXA mesotherapy
Comparison of Cyspera vs. Tranexamic acid mesotherapy in a randomised clinical study of 54 melasma patients.7
– Archive of Dermatological Research
Scientis introduces the NEW Cysteamine Isobionic-Amide ComplexTM
The novel Cysteamine Isobionic-Amide ComplexTM activates powerful synergistic effects.
Cysteamine + Isobionic-Amide
Isobionic-Amide multiplies the pigment- correction efficacy of Cysteamine by inhibiting multiple steps in the melanogenesis pathway.10,11,12
Cysteamine + AHA
AHA stabilises Cysteamine, which enhances its permeability into the skin and reduces its smell on skin.13,14,15
Isobionic-Amide + AHA
AHA reacts immediately with Isobionic-Amide, which produces an instant pigment lightening.16
A 3-step approach for multiple effects
CYSPERA INTENSIVETM – Cysteamine Isobionic-Amid ComplexTM
delivers powerful antioxidant activity to improve the appearance of persistent brown patches and dark spots.9,17
• Cysteamine reduces melanin production in the melanogenesis pathway at multiple locations.
• AHA creates an acidic environment enhancing cysteamine permeability into the skin.21
• Isobionic-Amide with AHA immediate reaction leads to instant pigment lightening.22
Clinically proven to be more effective and faster than the gold-standard triple combination without the concerns of corticosteroids, retinoic-acid and hydroquinone.
18% more effective and 4x better tolerated after 16 weeks.20
Fast onset of action and 10% better evening of skin tone within 4 weeks.17
Significantly improves the quality of life of patients within 4 weeks.17
CYSPERA NEUTRALIZETM
AHA-Amino Acid Complex neutralises the smell of cysteamine and re-balances the epidermis before application of Cyspera BoostTM.22
• L-Arginine Complex stops Isobionic- Amide/AHA reaction.
• Mild Surfactant medium gently removes lingering residue, while helping soothe skin and promoting healthy skin barrier.
• Lactobionic Acid prepares the skin
for Cyspera BoostTM by neutralising and balancing the skin’s pH.
Neutralise smell of cysteamine:
77% of the patients think it neutralises the smell of cysteamine on the skin.22
Re-balance: 90% of the patients think it re-balances the skin after use of Intensive.22
Cleanse: 90% of the patients think it deeply cleanses the skin.22
Pleasant to use: 87% of the patients find it pleasant to use after
Cyspera IntensiveTM.22
CYSPERA BOOSTTM
The Isobionic-Amide ComplexTM works synergistically with Cyspera IntensiveTM to even skin tone, improve complexion and deliver a natural and healthy glow.17
- Isobionic-Amide multiplies the efficacy
of Cysteamine by inhibiting multiple steps of melanogenesis in the skin.24 - Retinol and an anti-oxidative complex provide a visual pigment-correction effect by increasing non-pigmented skin layers and shading.25
- Isobionic-Amide with Retinol provide an anti-inflammatory effect to the skin after application of Cyspera IntensiveTM.2
Brightening: 81% of the patients noticed improvement of skin complexion, and 71% of the patients find their skin more radiant and luminous.23
Skin Health: 84% of the patients find their skin smoother, and 77% of the patients feel their skin is visibly healthier.23
Pleasant to use: 94% of the patients find the product easy to apply, not sticky and easy to combine with other products.23
Pleasant smell: 90% of the patients find the smell pleasant.23
Mode of use: 15-minute short application Intensive phase: Once per day, every day, for 16 weeks or until the desired results are achieved.
Maintenance phase: Once per day, twice weekly.
It is important for the skin to acclimate to Cyspera IntensiveTM by limiting initial use to 5 minutes once per day. After one week, increase to 15 minutes’ exposure (or as advised by your doctor).
In case of irritation, discontinue use for a few days until your skin recovers, then restart application of Cyspera IntensiveTM for 5 minutes.
Use can be tailored to meet the needs of an individual patient and their routine. It can be applied in the morning or evening, offering patients true flexibility and personalised choice.
For optimal results, daily use of a broad-spectrum sunscreen with SPF 30 or higher is highly recommended.
Caution : For external use only. Do not use on damaged or irritated skin. Do not use in case of known allergy to a component. Discontinue use and consult a doctor if signs of irritation or allergy appear. Avoid contact with eyes. In case of eye contact, rinse off with clean water. Keep out of reach of children. Do not use for pregnant or lactating women. Use adapted solar protection in case of sun exposure.
The new Cysteamine Isobionic-Amide ComplexTM leverages the long-term efficacy from Scientis Cysteamine 5% and shows fast onset of action and better evening of skin tone within 4 weeks of use.
Clinical Study Observations at week 417:
- Cyspera® acts rapidly on pigment correction with significant mMASI Score reduction, on par with Triple Combination in comparison to baseline within 4 weeks.
- Cyspera® is more effective at evening skin tone within 4 weeks, with 10% greater reduction of contrast between lesional and non-lesional areas.
- Cyspera® improves the quality of life of patients within 4 weeks, with condition being significantly less bothersome after one month of regular test product usage.
